Elucidation of the mechanism
of near-infrared light-induced cell death
and method establishment for measuring therapeutic effects

Kazuhide Sato

Dr. Kazuhide Sato
Designated Assistant Professor (selected-YLC program)
Institute for Advanced Research/ School of Medicine,
Tokai National Higher Education and Research System, Nagoya University

*The organization and the title are those when awarded

Research summary

 The typical current cancer treatment such as radiation therapy and chemotherapy cause damage to normal cells. The damage will result in side effects and make QOL (Quality of Life) of patients getting worse.
 Dr. Sato has studied the next generation cancer specific therapy called Near Infrared Photoimmunotherapy (NIR-PIT), which can extremely decrease side effect of cancer therapy by targeting only cancer cells through antibody-probe complex. Cell death of targeted cells will be further triggered by reaction of probe and near infrared light. He also clarified the mechanism of cell death due to NIR-PIT and found out that dead cells can be quantified and estimated with near infrared fluorescence measurement.
Dr. Sato has contributed a prior application designation of NIR-PIT from the Pharmaceuticals and Medical Devices Agency in Japan. His work greatly contributes to society by making a breakthrough in both diagnosis and therapy of cancer.

triggered by reaction of probe and near infrared light. He also clarified the mechanism of cell death due to NIR-PIT and found out that dead cells can be quantified and estimated with near infrared fluorescence measurement.
 Dr. Sato has contributed a prior application designation of NIR-PIT from the Pharmaceuticals and Medical Devices Agency in Japan. His work greatly contributes to society by making a breakthrough in both diagnosis and therapy of cancer.

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Introduction to Research