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Dr. Hiroshi Yukawa, Designated Lecturer

Dr. Hiroshi Yukawa

Development of in vivo imaging diagnostic technique of transplanted stem cells by fluorescent measurement and elemental analysis of quantum dots

ImPACT Research Center for Advanced Nanobiodevices, Nagoya University

*The organization and the title are those when awarded

Research summary

Stem cell transplantation plays a large role in regenerative medicine.

The tracking of stem-cells is very essential after transplanted stem cells in vivo

However since the transplanted cells is small, they are not detected by conventional modalities such as Roentgen, CT, MRI and etcetera. 

Dr. Yukawa succeeded to transduce Quantum dots (QDs) into stem cells with high efficiency, to achieve a long-term quantitative tracking the transplanted cells by using QDs. 

They can show the strong fluoresce in near-infrared region. 

Furthermore he could track multi-transplanted cells by using QDs which are different wavelength of emission. 

This study is expected to contribute transplantation techniques for stem cells which as represented by iPS cells.

*Quantum dots (QDs): It is nanocrystal made of semiconductor material, has strong fluorescence, emission wavelength depended to length of radius, can be same excitated wavelength.
*Stem cell: It is undifferentiated cells which can differentiate tissues, organs and etcetera.
*in vivo: "within the living"