Dr. Manabu Tokeshi, Assistant Professor

Dr. Manabu Tokeshi

Development of Ultrasensitive and Rapid Analysis Methods by Combining Laser Spectroscopy and Microdevice

Nagoya University

*The organization and the title are those when awarded

Abstract

  • 日本語
  • English

レーザー分光法(非蛍光性物質は熱レンズ検出法,蛍光性物質は蛍光法)をベースにした超高感度検出技術の開発と,極微量試料を迅速・高感度に分析・計測することを可能にするマイクロデバイス技術の開発を行ってきた。両者を組み合わせることにより,極微量の生体由来物質(NOなどの低分子,タンパク質,DNA,細胞など)を超高感度かつ迅速に分析・計測することが可能となる。

Both ultrasensitive detection methods based on laser spectroscopy, (thermal lens spectroscopy for nonfluorescent molecules and fluorescence spectroscopy for fluorescent molecules) and microdevices that can rapidly measure ultra low-volume samples have been developed. By combining both technologies, high sensitive detection and rapid analysis of ultra low-volume biological samples (ex. nitric oxide, proteins, DNA, cells, and so forth) has successfully demonstrated.

Research summary

He has effectively utilized the μTAS technology for the innovation of measurement technology.

Especially, his contribution in improving practical applicability of TLM is highly evaluated.

In addition, he has achieved the ultra-sensitive measurement in real blood sample.

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